| 释义 |
epitope, n. Immunol.|ˈɛpɪtəʊp|
[f. epi- + Gr. τόπ-ος place.]
Any area of the surface of an antigen to which a particular antibody may bind with a high degree of specificity; an antigenic determinant.
1960N. K. Jerne in Ann. Rev. Microbiol. XIV. 342 The suffixes -tope and -type are used in words denoting certain units of immunological significance. An antigen particle carries several epitopes (= surface configurations, single determinants, structural themes, immunogenic elements, haptenic groups, antigenic patterns, specific areas). 1974Nature 29 Nov. 416/2 Another possibility would be that primitive antigen receptors..would be replaced..by receptors which would discriminate much more precisely among different epitopes. 1980Sci. Amer. July 40/3 The rabbit and human antigens had at least some epitopes in common, and the antibodies whose production the vaccine stimulated recognized and interacted with the human epitopes. 1987Nature 19 Feb. 722/2 We cannot rule out the possibility that the ‘off-diagonal’ 45K component observed in Fig. 4a carries a γ epitope. |