| 释义 |
ephedrine Med.|ˈɛfədrɪn|
Also -in.
[S. Nagai 1887, in Pharmazeut. Zeit. XXXII. 700, f. Ephedra (see prec.) + -ine5.]
An alkaloid, C10H15NO, that occurs in certain species of Ephedra in four optically active forms and is made synthetically; 2-methylamino-1-phenylpropanol; spec. one of the lævorotatory isomers, used in the form of its salts as a sympathomimetic drug.
1889Jrnl. Chem. Soc. LVI. 1020 Nagai, some years ago, isolated an alkaloïd, ephedrine, from the Ephedra vulgaris, but through lack of material was unable to do more than determine its physiological action. 1900Dorland Med. Dict., Ephedrin. 1929Irish Jrnl. Med. Sci. Apr. 184 In cases where the blood-pressure falls very low, ephedrin will control the fall. 1940Thorpe's Dict. Appl. Chem. (ed. 4) IV. 317/1 The difference between ephedrine and ψ-ephedrine is limited to the carbon atom bearing the hydroxyl group. 1949T. A. Henry Plant Alkaloids (ed. 4) 642 Being more stable to metabolic conditions, ephedrine can be given by mouth, whereas adrenaline has to be used by injection. 1967G. A. Swan Introd. Alkaloids ii. 9 As ephedrine has been used successfully in the treatment of bronchial asthma, hay fever and other allergic conditions, many syntheses of it have been devised. |