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单词 tamoxifen
释义 tamoxifen Pharm.|təˈmɒksɪfɛn|
[f. t (perh. f. trans) + amine + oxy- + phenol, with alteration of y and ph.]
An œstrogen antagonist, (CH3)2N(CH2)2·O·C6H4·(C6H5)C:C(C6H5)·CH2CH3, used to treat breast cancer and infertility in women.
1972Approved Names 1970 (Brit. Pharmacopœia Comm.) Suppl. iv. 6 Tamoxifen.1972Clin. Endocrinol. I. 275 A derivative of triphenylethylene was examined by Harper & Walpole (1967a,b) for its anti-oestrogenic activity in rats. This compound..was subsequently named tamoxifen.1980Brit. Med. Jrnl. 29 Nov. 1459/1 Lung metastases then enlarged and tamoxifen was substituted but discontinued after only two months because of progressive disease.
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