| 释义 |
Duchenne, n. Path.
(duːˈʃɛn, ‖ dyʃɛn)
The name of Guillaume Benjamin Amand Duchenne (1806–75), French neurologist, used attrib. and in the possessive (esp. as Duchenne muscular dystrophy) to designate the severe form of muscular dystrophy described by him, formerly called pseudohypertrophic muscular dystrophy; also in Comb. as Duchenne-type a., and ellipt. as Duchenne.
1870W. B. Kesteven in Jrnl. Mental Sci. XVI. 46, I believe we should herein only be doing justice if in future we shortened the lengthy title of ‘Pseudo-Hypertrophic Muscular Paralysis of Duchenne’ into the brief, though not very scientific, form—‘Duchenne's Paralysis’. 1896Duchenne's paralysis [see pseudo-hypertrophy s.v. pseudo- 2]. 1936Arch. Neurol. & Psychiatry (Chicago) XXXVI. 1296 Minkowski and Sidler, from studies in Switzerland, concluded that in the Duchenne type inheritance of the disease occurs as a recessive mendelian character. 1954Brain LXXVII. 185 In our opinion the group should be entitled simply ‘Duchenne type muscular dystrophy’. This group will include the traditional ‘pseudohypertrophic muscular dystrophy’. 1980Neurology XXX. 206/1 Detection of Duchenne carriers is usually based on serum creatine kinase (CK) activity. 1982T. M. Devlin Textbk. Biochem. xxi. 1005 A number of components in the sarcoplasm of skeletal muscle are found to be present in lower than normal levels in patients with Duchenne's muscular dystrophy. 1991Conquest Feb. 180 In 1987..the gene responsible for muscular dystrophy of the Duchenne type was finally isolated, localised and characterised in the Xp21 region of the..X chromosome. |