| 释义 |
diphenoxylate, n. Pharm.|daɪfɛˈnɒksɪleɪt|
[f. diphenyl n. + *carboxylate n.]
A tetracyclic derivative, C30H32N2O2 , of pethidine that reduces intestinal motility and is given orally as the hydrochloride in cases of diarrhoea and colitis.
1960Amer. Jrnl. Gastroenterol. XXXIV. 630 A new antidiarrheal agent, diphenoxylate hydrochloride, Lomotil (R-1132), was administered to 80 patients with diarrhea of various causes. 1976Brit. Med. Jrnl. 20 Nov. 1240/2 Diphenoxylate with atropine (Lomotil) is popular nowadays. 1984Brit. Nat. Formulary (B.M.A.) (ed. 8) 53/2 In chronic diarrhoeas..loperamide may be preferable to the centrally acting opiates (morphine, codeine, and diphenoxylate) as it is unlikely to cause dependence. |