| 释义 |
dihydropyridine, n. Chem. and Pharmacol.
Brit. |ˌdʌɪhʌɪdrə(ʊ)ˈpɪrɪdiːn|, U.S. |ˈˌdaɪhaɪdroʊˈpɪrəˌdin|, |ˈˌdaɪhaɪdroʊˈpɪrədn|
[‹ dihydro- comb. form + pyridine n., after German Dihydropyridin (1880 or earlier).]
Each of the five possible isomers produced by the double hydrogenation of pyridine; C5H7N. Also: any of various compounds derived from these; esp. any of a class of drugs derived from 1,4-dihydropyridine (in which the nitrogen and the carbon opposite to it in the pyridine ring are hydrogenated), which act as calcium channel blockers and are used chiefly for the treatment of hypertension and angina pectoris.
1886Philos. Trans. 1885 (Royal Soc.) 176518 According to Wischnegradsky..nicotine is an alkyl derivative of a di-hydro-pyridine. 1903Jrnl. Chem. Soc. 84 i. 651 In the present paper, evidence is adduced for the existence of open chain compounds, containing nitrogen, which..do not form dihydropyridines. 1949Jrnl. Amer. Chem. Soc. 71 4003/1 The first products obtained were all of the normal dihydropyridine type, and manifested weak analgesic and curare-like activities. 1972Jrnl. Pharmacy & Pharmacol. 24 917 (title) Dihydropyridines with potent hypotensive activity prepared by the Hantzsch reaction. 1989Science 10 Feb. 809 Nimodipine is one of several dihydropyridines that block calcium channels. 2000Saga Mag. Feb. 100/3 Dihydropyridine calcium antagonists are suitable alternatives for older patients when thiazides are ineffective or not tolerated. |