| 释义 |
streptozotocin Pharm.|strɛptəʊˈzɒtəsɪn|
[f. as prec. + -zoto-, of unkn. origin + -mycin.]
An antibiotic substance obtained from Streptomyces achromogenes that damages insulin-producing cells and is used to induce diabetes in laboratory animals.
1960J. J. Vaura et al. in Antibiotics Ann. 1959–60 234 Streptozotocin is a new antibiotic produced by a streptomycete isolated from the soil. 1972Jrnl. Pharm. Sci. LXI. 491/1 Chemically streptozotocin is a N-methyl-N-nitrosourea derivative..of d-glucosamine. 1976A. Marble et al. in G. S. Avery Drug Treatment xv. 421/1 Streptozotocin, another hyperglycaemic drug, has been similarly used in cases of malignant insulin-secreting tumour. 1980Nature 3 Jan. 100/1 Proinsulin mRNA was purified from rat B-cell tumours induced with streptozotocin and nicotinamide. |