| 释义 |
streptomycin Pharm.|strɛptəʊˈmaɪsɪn|
[f. prec.: see -mycin.]
An antibiotic, C21H39N7O12, produced by the soil bacterium Streptomyces griseus, which was the first drug to be successful against tuberculosis but is now used chiefly in conjunction with other drugs because of its toxic effects. Also Comb.
1944A. Schatz et al. in Proc. Soc. Exper. Biol. & Med. LV. 67/1 Because of its similarity to streptothricin, this substance may be designated as streptomycin, derived from the generic name that has recently been given to the aerial-mycelium producing and sporulating group of actinomycetes, namely Streptomyces. 1948‘G. Orwell’ Let. 4 Feb. in Coll. Ess. (1968) IV. 404 We are now sending for some new American drug called streptomycin which they say will speed up the cure. 1961Lancet 29 July 247/2 Streptomycin-resistant strains [of gonococci] remained..susceptible to penicillin. 1973Sci. Amer. Sept. 130/2 Streptomycin and isoniazid have diminished the need for state tuberculosis sanatoriums. 1974M. C. Gerald Pharmacol. xxvi. 457 Streptomycin binds to the ribosome in such a manner that incorrect amino acids are laid down, thus resulting in the formation of a nonfunctional protein. 1978Antimicrobial Agents & Chemotherapy XIII. 430 Combinations of penicillin and gentamycin have been shown to be synergistic against all strains of enterococci, including those resistant to penicillin and streptomycin. |