| 释义 |
dexamethasone Pharm.|ˌdɛksəˈmɛθəsəʊn, -zəʊn|
[f. dexa- (blend of hexa- and deca- in hexadecadrol (see quot. 19582), representing the number 16 in the systematic names) + methyl + -a + cortisone.]
A synthetic steroid, C22H29FO5, which resembles cortisone in its effects and is used in the treatment of some blood disorders and as an anti-inflammatory agent.
1958Arthritis & Rheumatism Aug. 330 Preliminary results of..investigations on the effect of dexamethasone in rheumatoid arthritis are encouraging. 1958Ann. Rheumatic Dis. Dec. 376 In December, 1957, four separate 16a-methylated derivatives of hydrocortisone were made available for clinical trial... 16a-methyl 9a-fluoroprednisolone first received the generic name of ‘hexadecadrol’, but this was later changed to ‘dexamethasone’. 1961Lancet 12 Aug. 348/2 The therapy was changed from triamcinolone to dexamethasone. 1968J. H. Burn Lect. Notes Pharmacol. (ed. 9) 95 Dexamethasone is a derivative of hydrocortisone, which is very much more active than hydrocortisone. |