| 释义 |
degranulation, n. Med.|ˌdiːgrænjʊˈleɪʃən|
[f. de- II. 1 + granulation n.]
The loss or disappearance of (esp. intracellular) granules.
1952Proc. Soc. Exper. Biol. & Med. LXXX. 678/1 Administration of cortisone and ACTH is followed by more or less marked degranulation. 1961Nature 9 Sept. 1057/1 Each of the five patients with a history of penicillin anaphylaxis showed significant degranulation of the basophils in the presence of penicillin in vitro. 1964W. G. Smith Allergy & Tissue Metabolism iii. 35 In tissues situated some distance from the site of injection, the mast cells were not destroyed but showed a sequence of swelling and degranulation followed by a recovery phase. 1974Nature 6 Dec. 488/2 The estimation of changes inflicted on the endoplasmic reticulum..(such as the in vitro displacement of ribosomes (degranulation) of the liver endoplasmic reticulum by carcinogens). 1986D. Male Immunol. vi. 88 Degranulation occurs when mast cell granules fuse with the plasma membrane, releasing their contents to the exterior. |