| 释义 |
degranulate, v. Med.|diːˈgrænjʊleɪt|
[f. de- II. 1 + granulate v.]
a. trans. To cause the degranulation of; to remove granules or granularity from.
1952[implied in *degranulated ppl. adj. below]. 1971Nature 9 July 104/2 Carbon tetrachloride degranulates rough membranes only after activation by the hydroxylase system. 1977Lancet 20 Aug. 389/1 Plasma or serum from this patient degranulated eosinophils from normal individuals, perhaps indicating an autoimmune mechanism.
b. intr. To undergo degranulation; to lose granules or granularity.
1963[implied in *degranulating ppl. adj. below]. 1978Nature 22 June 619/1 In the presence of reaginic antibody and antigen, mast cells degranulate, releasing vasoactive substances which cause increased mucosal permeability. 1982Sci. Amer. Aug. 85/1 The mast cell degranulates: the granules move to the surface of the cell and release their contents into the surrounding tissue. 1988Nature 22 Sept. 292/1 The issue of whether basophils degranulate at infinite concentrations of IgE in a cyclic manner..is of great scientific and clinical interest.
So deˈgranulated ppl. a., deˈgranulating vbl. n. and ppl. a.
1952Proc. Soc. Exper. Biol. & Med. LXXX. 678/1 In human patients the mast cells of dermal connective tissue decreased in number and became degranulated. 1963Jrnl. Amer. Med. Assoc. 20 Apr. 174/1 Rabbits in good health are regularly satisfactory, but occasionally degranulating cells will be seen in the control. 1975Nature 9 Oct. 511/1 Electron microscopic observations of haemostatic plugs in rabbits and dogs have shown that the platelets are mostly degranulated. 1989New Scientist 15 July 49/1 The drug sodium cromoglycate is known to prevent mast cells from releasing their mediators (degranulating). |